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Most acute side effects are dose-dependent and rate-dependent
Their results clearly show the role of glycemic control and the route of insulin administration in the normalization of IGF-1, IGFBP-1, and GH in patients with recent-onset T1DM
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Furthermore IGF-Is antioxidant capability in brain cortex and hippocampus was assessed as improving antioxidant enzymes activities (superoxide dismutase, catalase and glutathione peroxidase) and parameters of oxidative damage (MDA and PCC)[55, 56]
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